Summary: Clinical isolates of spp. were examined for their susceptibility to human serum. The susceptibility of the strains to immune and nonimmune human serum was dependent upon the size of the bacterial inoculum and the concentration of serum. There were differences among spp. in susceptibility to human serum: strains were the least susceptible, strains of and serotype 6 were intermediate, and those of other than serotype 6 and were the most susceptible. Experiments in which heat-treated (56 °C for 30 min, or 50 °C for 20 min) serum was used, and analysis of activation of complement by lipopolysaccharides (LPS) from each sp., suggested that LPS composition, especially the O antigen polysaccharide chains, contributes to the differences among spp. in susceptibility to human serum.


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