The Effect of Hormones on Free

Abstract

The hormonal milieu can alter susceptibility to infection. The effect of hormones on was studied utilizing axenically cultured clinical isolates. Oestrogens, in physiological concentrations, decreased the growth of the organisms and their attachment to mammalian cells , and acted as a chemorepellent. The specificity of these effects was verified by their being blocked with anti-oestrogens, by the dose- and time-dependency of the responses, and by the lack of effect with other hormones. These results suggest that oestrogens may decrease the virulence of ; however, interactions between oestrogens and mammalian cells may promote the development of infection. Thus complicated interactions between hormones, micro-organisms and mammalian cells must determine whether exposure to oestrogens predisposes to or prevents the development of infection.

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1988-06-01
2024-03-29
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References

  1. Alderete J. F., Garza G. E. 1985; Specific nature of Trichomonas vaginalis parasitism of host cell surfaces. Infection and Immunity 50:701–708
    [Google Scholar]
  2. Arnold J. D., Berger A. E., Martin D. C. 1969; Role of endocrine system in controlling growth and division synchrony of Plasmodium berghei in mice. Journal of Parasitology 55:956–962
    [Google Scholar]
  3. Azuma T. 1968; A study of the parasitizing condition of Trichomonas vaginalis with special reference to the relationship between estrogen and the growth of Trichomonas vaginalis. Journal of the Japanese Obstetrics and Gynecology Society 15:168–172
    [Google Scholar]
  4. Botta G. A. 1979; Hormonal and type-dependent adhesion of group B streptococci to human vaginal cells. Infection and Immunity 25:1084–1086
    [Google Scholar]
  5. Cappuccinelli P., Lattes C., Cagliani I., Ponzi A. N. 1974; Features of intravaginal Trichomonas vaginalis infection in the mouse and the effect of estrogen treatment and immunodepression. Giornale di batteriologia, virologia ed immunologia 67:31–40
    [Google Scholar]
  6. Christow P. 1971; Experiments on the influence of metabolites and antimetabolites on the model of Trichomonas vaginalis. VIII. Communication: experiments with hormones. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene I. Abt. Orig.A 218:542–552
    [Google Scholar]
  7. Csaba G., Lantgs T., Nagy S. U., Aranyi P., Naray A. 1978; Effects of steroids on Tetrahymena. Acta biologica et medica germanica 37:1377–1380
    [Google Scholar]
  8. Csaba G., Inczefi-Gonda A., Feher T. 1985; Induction of steroid binding sites (receptors) and presence of steroid hormones in the unicellular Tetrahymena pyriformis. Comparative Biochemistry and Physiology 82A:567–570
    [Google Scholar]
  9. Diamond L. S. 1983; Lumen dwelling protozoa: Entamoeba, trichomonads and Giardia. In In Vitro Cultivation of Protozoan Parasites pp 65–109 Jensen J. B. Edited by Boca Raton: CRC Press;
    [Google Scholar]
  10. El-Boulaqi H. A., El-Refaie S. A., Bassiouny G. A., Amin F. M. A. 1984; The relation between Trichomonas vaginalis and contraceptive measures. Journal of the Egyptian Society of Parasitology 14:495–499
    [Google Scholar]
  11. Forslin L., Danielsson D., Falk V. 1979; Variations in attachment of Neisseria gonorrhoeae to vaginal epithelial cells during the menstrual cycle and early pregnancy. Medical Microbiology and Immunology 167:231–238
    [Google Scholar]
  12. Hamana K., Iwai K. 1971; Effects of steroid hormones on the growth of Tetrahymena. Journal of Biochemistry 69:463–469
    [Google Scholar]
  13. Kita E., Takahashi S., Yasui K., Kashiba S. 1985; Effect of estrogen (17β-estradiol) on the susceptibility of mice to disseminated gonococcal infection. Infection and Immunity 49:238–243
    [Google Scholar]
  14. Linstead D. 1981; New defined and semi-defined media for cultivation of the flagellate Trichomonas vaginalis. Parasitology 83:125–137
    [Google Scholar]
  15. Loose D. S., Feldman D. 1982; Characterization of unique corticosterone-binding protein in Candida albicans. Journal of Biological Chemistry 257:4925–4930
    [Google Scholar]
  16. Martinotti M. G., Savoia D. 1985; Influenza di alcuni ormoni steroidei sulla crescita di Trichomonas vaginalis. Giornale di batteriologia, virologia ed immunologia 78:52–59
    [Google Scholar]
  17. Martinotti M. G., Martinetto P., Savoia D. 1986; Adherence of Trichomonas vaginalis to cell culture monolayers. European Journal of Clinical Microbiology 5:320–323
    [Google Scholar]
  18. Powell B. L., Drutz D. J., Huppert M., Sun S. H. 1983; Relationship of progesterone- and estradiol-binding proteins in Coccidioides immitis to coccidioidal dissemination in pregnancy. Infection and Immunity 40:478–485
    [Google Scholar]
  19. Pung O. J., Luster M. I., Hayes H. T., Rader J. 1984; Influence of steroidal and nonsteroidal sex hormones on host resistance in mice: increased susceptibility to Listeria monocytogenes after exposure to estrogenic hormones. Infection and Immunity 46:301–307
    [Google Scholar]
  20. Pung O. J., Tucker A. N., Vore S. J., Luster M. I. 1985; Influence of estrogen on host resistance: increased susceptibility of mice to Listeria monocytogenes correlates with depressed production of interleukin 2. Infection and Immunity 50:91–96
    [Google Scholar]
  21. Schär G., Stover E. P., Clemons K. V., Feldman D., Stevens D. A. 1986; Progesterone binding and inhibition of growth in Trichophyton mentagrophytes. Infection and Immunity 52:763–767
    [Google Scholar]
  22. Stover E. P., Schär G., Clemons K. V., Stevens D. A., Feldman D. 1986; Estradiol-binding proteins from mycelial and yeast-form cultures of Paracoccidioides brasiliensis. Infection and Immunity 51:199–203
    [Google Scholar]
  23. Sugarman B., Agbor P. 1986; Estrogens and Chlamydia trachomatis. Proceedings of the Society for Experimental Biology and Medicine 183:125–131
    [Google Scholar]
  24. Sugarman B., Epps L. R. 1982; Effect of estrogens on bacterial adherence to HeLa cells. Infection and Immunity 35:633–638
    [Google Scholar]
  25. Weiss M., Ingbar S. H., Winblad S., Kasper D. L. 1983; Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica. Science 219:1331–1333
    [Google Scholar]
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