RT Journal Article SR Electronic(1) A1 Tomás, Juan M. A1 Ciurana, Blanca A1 Benedí, Vicente J. A1 Juarez, AntonioYR 1988 T1 Role of Lipopolysaccharide and Complement in Susceptibility of Escherichia coli and Salmonella typhimurium to Non-immune Serum JF Microbiology, VO 134 IS 4 SP 1009 OP 1016 DO https://doi.org/10.1099/00221287-134-4-1009 PB Microbiology Society, SN 1465-2080, AB The role of lipopolysaccharide (LPS) in the susceptibility of Escherichia coli and Salmonella typhimurium to non-immune human serum was investigated using serum-sensitive strains of both enterobacteria. LPS from serum-resistant strains of E. coli and S. typhimurium could activate and completely remove the serum bactericidal activity, and also showed dose-dependent anti-complement activity. These properties were mainly due to the high-molecular-mass LPS: the low-molecular-mass LPS from serum-resistant strains of E. coli and S. typhimurium had only a slight effect on the serum bactericidal activity, and showed only low anti-complement activity, even at high concentration. The results suggest that LPS composition, especially the O-antigen polysaccharide chains, contributes to the susceptibility of E. coli and S. typhimurium strains to complement-mediated serum bactericidal activity., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-134-4-1009