@article{mbs:/content/journal/micro/10.1099/00221287-134-4-1009, author = "Tomás, Juan M. and Ciurana, Blanca and Benedí, Vicente J. and Juarez, Antonio", title = "Role of Lipopolysaccharide and Complement in Susceptibility of Escherichia coli and Salmonella typhimurium to Non-immune Serum", journal= "Microbiology", year = "1988", volume = "134", number = "4", pages = "1009-1016", doi = "https://doi.org/10.1099/00221287-134-4-1009", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-134-4-1009", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "The role of lipopolysaccharide (LPS) in the susceptibility of Escherichia coli and Salmonella typhimurium to non-immune human serum was investigated using serum-sensitive strains of both enterobacteria. LPS from serum-resistant strains of E. coli and S. typhimurium could activate and completely remove the serum bactericidal activity, and also showed dose-dependent anti-complement activity. These properties were mainly due to the high-molecular-mass LPS: the low-molecular-mass LPS from serum-resistant strains of E. coli and S. typhimurium had only a slight effect on the serum bactericidal activity, and showed only low anti-complement activity, even at high concentration. The results suggest that LPS composition, especially the O-antigen polysaccharide chains, contributes to the susceptibility of E. coli and S. typhimurium strains to complement-mediated serum bactericidal activity.", }