@article{mbs:/content/journal/micro/10.1099/00221287-134-3-719, author = "Taylor, D. and Holland, K. T.", title = "Effect of Dilution Rate and Mg2+ Limitation on Toxic Shock Syndrome Toxin-1 Production by Staphylococcus aureus Grown in Defined Continuous Culture", journal= "Microbiology", year = "1988", volume = "134", number = "3", pages = "719-723", doi = "https://doi.org/10.1099/00221287-134-3-719", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-134-3-719", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = " A toxic shock syndrome isolate of Staphylococcus aureus was grown in a chemostat, in a defined synthetic medium of six amino acids, glucose, two vitamins and salts. Steady states were achieved under limiting and replete Mg2+ conditions and at a range of relative specific growth rates. The biomass and toxic shock syndrome toxin-1 (TSST-1) were estimated at each condition. Under Mg2- limitation the biomass and TSST-1 production rates were reduced compared to Mg2+ replete conditions. Optimal TSST-1 production occurred at 0.81 relative specific growth rate.", }