1887

Abstract

SUMMARY: Three extracellular proteases produced by during growth in liquid medium were examined for their effects on human α-1-antitrypsin (α-1-AT). One of these proteases, tissue-destructive protease (TDP) destroyed completely the trypsin-inhibitory capacity of α-1-AT at protease: inhibitor molar ratios down to 0.002:1. After inactivation by TDP, the of α-1-AT was reduced by 5000 in SDS-PAGE. This suggested that inactivation entailed only limited cleavage.

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/content/journal/micro/10.1099/00221287-134-2-481
1988-02-01
2019-10-17
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-134-2-481
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