1887

Abstract

The effect of purified human interferon-? on the responsiveness of human neutrophils was investigated. Pre-incubation of neutrophils with 100 U interferon ml for 10 min at 37C resulted in a 2.5-fold increase in -formylmethionyl-leucyl-phenylalanine-stimulated reactive oxygen metabolite generation (as assayed by luminol-dependent chemiluminescence). Pretreatment of neutrophils with interferon also potentiated their ability to kill , and thus it is proposed that this lymphokine may also enhance neutrophil function under certain pathological conditions.

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1988-01-01
2021-10-22
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