SUMMARY: Biochemical, microbiological and genetic studies were done to characterize the mechanism of bacterial formation of -nitrosomorpholine (NMOR) from morpholine and nitrite at neutral pH. In and , the nitrosating activity was markedly induced when bacteria were cultured under anaerobiosis in minimal medium containing nitrate, while in the presence of nitrite there was no induction. However, induction of the nitrosating activity in occurred in anaerobic cultures in the presence of either nitrate or nitrite. The nitrosation capacity was also examined in various K12 mutants whose structural gene of either nitrate reductase or nitrite reductase was deleted. Nitrosation was not linked to the three (NADH-, formate- and glucose-dependent) nitrite reductases but was directly dependent on the presence of a nitrate reductase.


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