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The nucleotide sequence of the DNA fragment containing the streptomycin 6-phosphotransferase (streptomycin 6-kinase) gene from the streptomycin-producer Streptomyces griseus strain HUT 6037 was determined. Analysis of the sequence revealed an open reading frame which could encode 325 amino acid residues. A biased codon usage pattern, reflecting the high G + C composition (approximately 74%) of Streptomyces DNA, was observed in the gene.
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