1887

Abstract

At least two aminoglycoside-resistance determinants from have been cloned separately in . In each case, resistance (to kanamycin plus apramycin or to kanamycin plus gentamicin) was expressed at the level of the ribosome and involved specific methylation of 16S ribosomal RNA. Hybridization and restriction analysis revealed that related genes were present in other aminoglycoside-producing actinomycetes.

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1987-04-01
2022-01-17
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