SUMMARY: The budding yeast Saccharomyces cerevisiae and the fission yeast were grown under CO pressure. Cell division was inhibited in both yeasts; RNA and protein content per cell declined but DNA continued to be synthesized and, in the case of , reached twice the normal level within 24 h. Changes in mean cell volume occurred in both yeasts within 1 h; an increase occurred in the budding yeast while a decrease was observed in the fission yeast. The results suggest that CO may exert its influence on cell characteristics through a change in cell volume.


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