SUMMARY: The incorporation of specifically labelled sugars into alginate by mucoid strains of both and resulted in substantially different labelling patterns for fructose and glucose. Alginate was synthesized principally from degradation products of glucose, whereas the majority of the polymer produced from fructose was assembled from intact hexose units. A possible explanation for the limited synthesis of alginate from undegraded glucose molecules is that one of the necessary enzymes, glucose-phosphate isomerase, is subject to inhibition by 6-phosphogluconate, a metabolite involved in the catabolism of sugars via the Entner-Doudoroff pathway in both of the organisms.


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