SUMMARY: A library of DNA was constructed using a cosmid cloning system. Sixteen hundred recombinant clones were generated covering the genome with a probability of 99%. Three hundred of the clones were screened for expression of antigens by a modified rocket immunoelectrophoresis technique using a polyspecific antiserum to . One clone was identified which produced the ‘common antigen' (CA) of (Tp-4). CA shares epitopes with antigens present in more than 50 different bacterial species, but nothing is known about its structure, function and localization. The recombinant clone will be of value for a structural analysis of the CA gene.


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