SUMMARY: Resistance to the aminoglycosides gentamicin (Gm), tobramycin (Tm) and kanamycin (Km) in strains of isolated in Australia is mediated by the transposon Tn. The 1·35 kb inverted repeat of this transposon exhibits many of the characteristics of an insertion sequence and has consequently been designated IS. Tandem duplication of IS contiguous with Tn results in an increase in the level of GmTmKm, thereby implying that the element possesses strong promoter sequences. Both contiguous and independent insertions of IS into the staphylococcal chromosome have been observed, the latter suggesting that the element may play a role in molecular rearrangements of the genome.


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