RT Journal Article SR Electronic(1) A1 Guhathakurta, Bhakti A1 Majumdar, Mita A1 Sen, Ashis K. A1 Sasmal, Dipti A1 Mukherjee, Amal K. A1 Datta, ArchanaYR 1986 T1 Immunochemical Properties of the Lipopolysaccharide O-Antigen of Vibrio cholerae O1 in Relation to Its Chemical Structure JF Microbiology, VO 132 IS 6 SP 1641 OP 1646 DO https://doi.org/10.1099/00221287-132-6-1641 PB Microbiology Society, SN 1465-2080, AB D-Glucuronic acid and D-glucosamine have an immunodominant role in the lipopolysaccharide (LPS) O-antigen of both the Ogawa and the Inaba subtypes of Vibrio cholerae O1. This was evident from the pronounced inhibitory effect on the LPS precipitin reaction demonstrated by these monosaccharides and by oligosaccharides containing either of them which were isolated from LPS hydrolysate. There was a considerable decrease in the antibody-combining capacity of chemically modified LPS in which the carboxyl group of the glucuronic acid had been reduced. Similarly, on deamination, the O-specific polysaccharide fraction of the LPS molecule from both subtypes completely lost the ability to precipitate the LPS antibody., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-132-6-1641