RT Journal Article SR Electronic(1) A1 Gibbons, Gwendolyn F. A1 Howard, Dexter H.YR 1986 T1 Arginine Auxotrophs of Candida albicans Deficient in Argininosuccinate Lyase JF Microbiology, VO 132 IS 2 SP 263 OP 268 DO https://doi.org/10.1099/00221287-132-2-263 PB Microbiology Society, SN 1465-2080, AB Summary: Auxotrophic mutants of Candida albicans FC18 were induced by a combination of treatments with nitrous acid and UV irradiation. Arginine (Arg−), histidine (His−) and methionine/cysteine (MetA−) auxotrophs were recovered by this means. The Arg− auxotrophs lacked active argininosuccinate lyase (EC 4.3.2.1), the enzyme catalysing the final step in arginine biosynthesis. Thus the locus may be designated arg-4. The mutant strains bearing this mutation did not form germ tubes unless the germination medium contained arginine., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-132-2-263