SUMMARY: We have developed a convenient system for genetic analysis of exploiting the properties of the mutator phage Mu. In spite of the fact that wild-type strains do not allow Mu to form plaques on them, we have shown that these strains are actually sensitive to the phage. It proved possible to use Mu to induce mutations and to promote intra- and interspecific genetic transfer, without having to introduce the phage into the bacteria by means other than infection. Furthermore, we isolated derivatives on which Mu formed plaques, and studied the behaviour of Mu in these and wild-type strains.


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