SUMMARY: The permeability parameter () for the movement of cephalosporin C across the outer membrane of was measured using the widely accepted method of Zimmermann & Rosselet. In one experiment, the value of varied continuously from 4·2 to 10·8 cm min (mg dry wt cells) over a range of concentrations of the test substrate, cephalosporin C, from 50 to 5 μ. Dependence of on the concentration of test substrate was still observed when the effect of a possible electric potential difference across the outer membrane was corrected for. In quantitative studies of β-lactam permeation the dependence of on the concentration of β-lactam should be taken into account.


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