RT Journal Article SR Electronic(1) A1 Chapman, Alan A1 Cammack, Richard A1 Linstead, David A1 Lloyd, DavidYR 1985 T1 The Generation of Metronidazole Radicals in Hydrogenosomes Isolated from Trichomonas vaginalis JF Microbiology, VO 131 IS 09 SP 2141 OP 2144 DO https://doi.org/10.1099/00221287-131-9-2141 PB Microbiology Society, SN 1465-2080, AB Summary: The nitro radical-anion of the anti-trichomonal drug metronidazole has been detected by electron spin resonance spectrometry under anaerobic conditions in suspensions of intact hydrogenosomes isolated from the parasitic protozoon Trichomonas vaginalis. Metronidazole reduction was driven by pyruvate, but progressive damage to the radical generating system was observed. Quenching of signals due to metronidazole radicals by chromium oxalate suggests that the radicals generated within the organelle can cross the hydrogenosomal membrane into the external medium. Even if a similar process of radical migration occurs in vivo, it seems likely that intrahydrogenosomal damage may explain drug action., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-131-9-2141