1887

Abstract

Summary: Puromycin is a potent inhibitor of bacterial protein synthesis, but puromycin-producing KCC S-0309 is tolerant to the antibiotic . Puromycin bound to both 30S and 50S ribosomal subunits from and inhibited polyuridylate-directed polyphenylalanine synthesis by the ribosomes. However, the organism possessed a novel puromycin-inactivating enzyme which acetylated the antibiotic at the 2″-NH group of the -methyltyrosine moiety.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-131-8-1999
1985-08-01
2021-05-17
Loading full text...

Full text loading...

/deliver/fulltext/micro/131/8/mic-131-8-1999.html?itemId=/content/journal/micro/10.1099/00221287-131-8-1999&mimeType=html&fmt=ahah

References

  1. Benveniste R., Davies J. 1973; Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proceedings of the National Academy of Sciences of the United States of America 70:2276–2280
    [Google Scholar]
  2. Cundliffe E. 1978; Mechanism of resistance to thiostrepton in the producing-organism Streptomyces azureus . Nature, London 272:792–795
    [Google Scholar]
  3. Cundliffe E., Thompson J. 1979; Ribose methylation and resistance to thiostrepton. Nature, London 278:859–861
    [Google Scholar]
  4. Cundliffe E., Thompson J. 1981; The mode of action of noshiheptide (multiomycin) and the mechanism of resistance in the producing organism. Journal of General Microbiology 126:185–192
    [Google Scholar]
  5. Grant P. G., Olson H. M., Gliz D. G., Cooperman B. S. 1983; Puromycin binding to the small subunits of Escherichia coli ribosomes. Journal of Biological Chemistry 258:11305–11312
    [Google Scholar]
  6. Hotta K., Yamamoto H., Okami Y., Umezawas H. 1981; Resistance mechanisms of kanamycin-, neomycin-, and streptomycin-producing streptomycetes to aminoglycoside antibiotics. Journal of Antibiotics 34:1175–1182
    [Google Scholar]
  7. Keeratipibul S., Sugiyama M., Nomi R. 1983; Mechanism of resistance to streptothricin of a producing microorganism. Biotechnology Letters 5:441–446
    [Google Scholar]
  8. Malik V. S., Vining L. C. 1972; Chloramphenicol resistance in a chloramphenicol-producing Streptomyces . Canadian Journal of Microbiology 18:583–590
    [Google Scholar]
  9. Nathans D., Lipmann F. 1961; Amino acid transfer from aminoacyl-ribonucleic acids to protein on ribosomes of Escherichia coli . Proceedings of the National Academy of Sciences of the United States of America 47:496–504
    [Google Scholar]
  10. Nimi O., Sugiyama M., Kameoka H., Tomoeda H., Ono K., Nomi R. 1981; Fate of streptomycin in mycelium of producer organism. Biotechnology Letters 3:239–244
    [Google Scholar]
  11. Olson H. M., Grant P. G., Cooperman B. S., Glitz D. G. 1982; Immunoelectron microscopic localization of puromycin binding on the large subunit of the Escherichia coli ribosome. Journal of Biological Chemistry 257:2649–2656
    [Google Scholar]
  12. Pérez-González J. A., Vara J., Jiménez A. 1983; Acetylation of puromycin by Streptomyces alboniger, the producing organism. Biochemical and Biophysical Research Communications 113:772–777
    [Google Scholar]
  13. Satoh A., Ogawa H., Satomura Y. 1975; Effect of sclerin on production of the aminoglycoside antibiotics accompanied by salvage function in Streptomyces . Agricultural and Biological Chemistry 39:1593–1598
    [Google Scholar]
  14. Shaw W. V., Hopwood D. A. 1976; Chloramphenicol acetylation in Streptomyces . Journal of General Microbiology 94:159–166
    [Google Scholar]
  15. Skinner R. H., Cundliffe E. 1980; Resistance to the antibiotics viomycin and capreomycin in the Streptomyces species which produce them. Journal of General Microbiology 120:95–104
    [Google Scholar]
  16. Skinner R. H., Cundliffe E. 1982; Dimethylation of adenine and the resistance of Streptomyces erythreus to erythromycin. Journal of General Microbiology 128:2411–2416
    [Google Scholar]
  17. Sugiyama M., Kobayashi H., Nimi O., Nomi R. 1980; Susceptibility of protein synthesis to streptomycin in streptomycin-producing Streptomyces griseus . FEBS Letters 110:250–252
    [Google Scholar]
  18. Sugiyama M., Mochizuki H., Nimi O., Nomi R. 1981a; Roles of streptomycin 6-kinase and ribosomal affinity to streptomycin in self-protection of streptomycin producer. Biotechnology Letters 3:357–362
    [Google Scholar]
  19. Sugiyama M., Mochizuki H., Nimi O., Nomi R. 1981b; Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain. Journal of Antibiotics 34:1183–1188
    [Google Scholar]
  20. Sugiyama M., Mochizuki H., Nimi O., Nomi R. 1982; Assessment of competitive action of streptomycin 6-kinase and streptomycin 6-phosphatase in the in vitro protein synthesis of a streptomycin-producing microorganism. FEBS Letters 139:331–333
    [Google Scholar]
  21. Sugiyama M., Sakamoto M., Mochizuki H., Nimi O., Nomi R. 1983; Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin-producing micro-organism. Journal of General Microbiology 129:1683–1687
    [Google Scholar]
  22. Teraoka H., Tanaka K. 1974; Properties of ribosomes from Streptomyces erythreus and Streptomyces griseus . Journal of Bacteriology 120:316–321
    [Google Scholar]
  23. Thompson C. J., Ward J. M., Hopwood D. A. 1980; DNA cloning in Streptomyces: resistance genes from antibiotic-producing species. Nature, London 286:525–527
    [Google Scholar]
  24. Thompson J., Cundliffe E. 1981; Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton. Journal of General Microbiology 124:291–297
    [Google Scholar]
  25. Thompson J., Cundliffe E., Stark M. J. R. 1982; The mode of action of berninamycin and the mechanism of resistance in the producing organism, Streptomyces bernensis . Journal of General Microbiology 128:875–884
    [Google Scholar]
  26. Yamamoto H., Hotta K., Okami Y., Umezawa H. 1981; Self-resistance of a Streptomyces which produces istamycin. Journal of Antibiotics 34:824–829
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-131-8-1999
Loading
/content/journal/micro/10.1099/00221287-131-8-1999
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error