RT Journal Article SR Electronic(1) A1 León, Javier A1 García-Lobo, Juan María A1 Navas, Jesús A1 Ortiz, Jose MiguelYR 1985 T1 Fosfomycin-resistance Plasmids Determine an Intracellular Modification of Fosfomycin JF Microbiology, VO 131 IS 7 SP 1649 OP 1655 DO https://doi.org/10.1099/00221287-131-7-1649 PB Microbiology Society, SN 1465-2080, AB Summary: Escherichia coli cells carrying fosfomycin-resistance plasmids modify fosfomycin intracellularly. The product of this modification (fosfomycin-derivative) differs from fosfomycin in chromatographic mobility, but the chemical nature of the modification is not yet known. Fosfomycin-derivative appears to have a cytoplasmic location and lacks antibiotic activity. The modification system can be saturated by an excess of fosfomycin in the incubation media., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-131-7-1649