1887

Abstract

Hygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70S and 80S ribosomes, is synthesized by Ribosomes from this Gram-positive mycelial bacterium are inhibited by the antibiotic. In contrast, the streptomycete is highly resistant to the drug since it possesses hygromycin B phosphotransferase activity. This enzyme has been shown by gel filtration to have a molecular weight of 42000, and to modify its antibiotic substrate to produce 7″--phosphoryl-hygromycin B which totally lacks biological activity both and .

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1985-06-01
2021-08-04
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