@article{mbs:/content/journal/micro/10.1099/00221287-131-4-935, author = "DALE*, J.W. and SMITH, J.T.", title = "Escherichia coli Thymine Auxotrophs Suppressible by Carbon Dioxide", journal= "Microbiology", year = "1985", volume = "131", number = "4", pages = "935-938", doi = "https://doi.org/10.1099/00221287-131-4-935", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-131-4-935", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Two independently-isolated thymine-requiring mutant strains of Escherichia coli were found to possess an unusual phenotype: in the presence of CO2, growth was independent of thymine. The two strains showed different profiles of temperature sensitivity. Glycine, serine and methionine were unable to relieve the thymine-dependence. Both strains were susceptible to trimethoprim under conditions where they were thymine-independent. The results are consistent with the occurrence of partial defects in thymidylate synthase.", }