1887

Microbiology

Volume 131, Issue 4

Mechanism of Action of Nikkomycin and the Peptide Transport System of Free

Abstract

Nikkomycin was found to be a potent growth inhibitor of through competitive inhibition of chitin synthase [ = 0·16 μ (0·1 μg ml)]. The activity of the peptide-nucleoside drug was antagonized by both peptone and defined peptides. Transported dipeptides were effective antagonists while transported oligopeptides were not. A mutant of resistant to the effects of nikkomycin through a transport defect was unable to transport dipeptides, while oligopeptide uptake was apparently unaffected. At least two peptide permeases are operational in this organism.

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© Society for General Microbiology 1985
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1985-04-01
2021-10-23
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Mechanism of Action of Nikkomycin and the Peptide Transport System of Candida albicans
Microbiology 131, 775 (1985); https://doi.org/10.1099/00221287-131-4-775
/content/journal/micro/10.1099/00221287-131-4-775
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