1887

Abstract

Nikkomycin was found to be a potent growth inhibitor of through competitive inhibition of chitin synthase [ = 0·16 μ (0·1 μg ml)]. The activity of the peptide-nucleoside drug was antagonized by both peptone and defined peptides. Transported dipeptides were effective antagonists while transported oligopeptides were not. A mutant of resistant to the effects of nikkomycin through a transport defect was unable to transport dipeptides, while oligopeptide uptake was apparently unaffected. At least two peptide permeases are operational in this organism.

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/content/journal/micro/10.1099/00221287-131-4-775
1985-04-01
2021-10-23
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