1887

Abstract

The addition of tribromo-, tetrabromo- and chloromethanes to cultures of strongly stimulated aflatoxin biosynthesis. The presence of phenobarbital in the cultures enhanced this effect. Following the addition of CC1 to a culture, after 15 d incubation, 8·6% of the total radioactivity was recovered from the mycelium, and 4·7% from the culture filtrate. Some 0·4% of the total radioactivity was found in microsomes, indicating their involvement in CC1 activation and biotransformation.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-131-3-687
1985-03-01
2021-07-28
Loading full text...

Full text loading...

/deliver/fulltext/micro/131/3/mic-131-3-687.html?itemId=/content/journal/micro/10.1099/00221287-131-3-687&mimeType=html&fmt=ahah

References

  1. Bhatnagar R. K., Ahmad S., Kohli K. K., Mukerji K. G., Venkitasubramanian T. A. 1982; Induction of polysubstrate monoxygenase and aflatoxin production by phenobarbitone in Aspergillus parasiticus . Biochemical and Biophysical Research Communications 104:1287–1292
    [Google Scholar]
  2. Buege J. A., Aust S. D. 1978; Microsomal lipid peroxidation. Methods in Enzymology 51:301–310
    [Google Scholar]
  3. Fabbri A. A., Fanelli C, Panfili G., Passi S., Fasella P. 1983; Lipoperoxidation and aflatoxin biosynthesis by Aspergillus parasiticus and A.flavus . Journal of General Microbiology 129:3447–3452
    [Google Scholar]
  4. Fanelli C, Fabbri A. A., Passi S. 1980; Growth requirements and lipid metabolism of Aspergillus flavus . Transactions of the British Mycological Society 75:371–375
    [Google Scholar]
  5. Fanelli C, Fabbri A. A., Finotti E., Panfili G., Passi S. 1983a; Cerulenin and tetrahydroceru- lenin: stimulating factors of aflatoxin biosynthesis. Transactions of the British Mycological Society 81:201–204
    [Google Scholar]
  6. Fanelli C, Fabbri A. A., Finotti E., Passi S. 1983b; Stimulation of aflatoxin biosynthesis by lipophilic epoxides. Journal of General Microbiology 129:1721–1723
    [Google Scholar]
  7. Fanelli C, Fabbri A. A., Passi S., Fasella P. 1983c; Control mechanisms of aflatoxin production. International Mycotoxin SymposiumSydneyAugust12-15 1983 Abst. P9
    [Google Scholar]
  8. Fanelli C, Fabbri A. A., Finotti E., Fasella P., Passi S. 1984; Free radicals and aflatoxin biosynthesis. Experientia 40:191–193
    [Google Scholar]
  9. Fowler J. S. L. 1969; Carbon tetrachloride metabolism in the rabbit. British Journal of Pharmacology 37:733–737
    [Google Scholar]
  10. Orrenius S., Ernster L. 1964; Phenobarbital-induced synthesis of the oxidative demethylating enzymes of rat liver microtomes. Biochemical and Biophysical Research Communications 16:60–64
    [Google Scholar]
  11. Passi S., Rothschild-Boros M. C, Fasella P., Nazzaro-Porro M., Whitehouse D. 1981; An application of high performance liquid chromato-graphy to analysis of Iipids in archeological samples. Journal of Lipid Research 22:778–784
    [Google Scholar]
  12. Passi S., Nazzaro-Porro M., Fanelli C, Fabbri A. A., Fasella P. 1984; Role of lipoperoxidation in aflatoxin production. Applied Microbiology and Biotechnology 19:186–190
    [Google Scholar]
  13. Reynolds E. S., Moslen M. T. 1980; Free radical damage in liver. In Free Radicals in Biology IV49–94 Pryor A. A. New York: Academic Press;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-131-3-687
Loading
/content/journal/micro/10.1099/00221287-131-3-687
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error