Summary: Regulation of NAD biosynthesis was examined through the construction of fusions in The (17 unit map position) and (55 units) genetic loci involved with quinolinic acid biosynthesis were both found to be regulated by the product of a locus (99 units) in a repression/derepression manner while (3 units) expression appeared constitutive at the transcriptional level. Increases in transcription directly correlated with decreases in intracellular NAD(P) levels, and kinetic studies indicated that the NAD analogue 6-aminoNAD was ineffective in repressing either or The presence of cAMP + cAMP receptor protein was essential for the complete derepression of while no effect was evident upon Transfer of cultures from aerobic to anaerobic conditions, however, resulted in the partial derepression of both and Thus, there appears to be a very complex set of controls regulating NAD biosynthesis.


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