@article{mbs:/content/journal/micro/10.1099/00221287-131-1-47, author = "KÄPPELI, OTHMAR and GSCHWEND-PETRIK, MAGDALENA and FIECHTER, ARMIN", title = "Transient Responses of Saccharomyces uvarum to a Change of the Growth-limiting Nutrient in Continuous Culture", journal= "Microbiology", year = "1985", volume = "131", number = "1", pages = "47-52", doi = "https://doi.org/10.1099/00221287-131-1-47", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-131-1-47", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "The transition of Saccharomyces uvarum from oxidative to oxido-reductive glucose metabolism was characterized by the immediate formation of ethanol and the gradual adaptation of cells to a new physiological state, as expressed by a decrease in mitochondrial cytochrome content and a loss of malate dehydrogenase activity. Shifting the cells from carbon-limited to oxygen-, nitrogen- and iron-limited media in a continuous culture growing oxidatively led to the initiation of the same effects. The results lend support to the concept of a limited respiratory capacity as the basis for the occurrence of oxido-reductive glucose metabolism. Limitation of growth by a nutrient other than glucose results in an imbalance between glucose flux and biosynthetic potential of the cells and causes oxido-reductive glucose breakdown.", }