SUMMARY: Cells of the yeast of the a mating type were arrested at the G1 phase of the cell division cycle after treatment with α factor in a culture medium containing a high concentration (2%, w/v, or higher) of a catabolite-repressing sugar. In media containing either a lower concentration of sugar or a non-fermentable carbon source, the extent of G1 arrest induced by the pheromone was reduced or became undetectable. Under catabolite-derepressing conditions α factor was inactivated by cells at a higher rate than that found in repressing media. These results indicate the existence of a close correlation between the action of α factor on cells and conditions of catabolite repression or derepression. A joint mechanism of action of aα factor and catabolite-repressing carbon sources on cells is postulated.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error