SUMMARY: The uptake of α-aminoisobutyrate (AIB) by washed cell suspensions of bloodstream forms of has been shown to be an energy-dependent process. No metabolism of AIB was detected under conditions leading to a 100-fold accumulation of AIB within the organism. Kinetic studies revealed that AIB uptake involved two components; that operating at low substrate concentrations had an apparent of 4.6 mM. Experiments with ionophores such as gramicidin and carbonylcyanide -chlorophenylhydrazone were consistent with the AIB uptake system operating as a H-symporter responding to the electrochemical gradient of H, the major component of which was the membrane potential.


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