1887

Abstract

Catalase activity in liver homogenates was studied in normal and low endotoxin (LPS) responder mice treated with various doses of LPS from B or bearing tumours induced by 3-methylcholanthrene. In normal LPS-responder (C3H/f) mice a dose of 40 μg LPS or tumour induction caused a reduction of catalase activity of about 50%. In low responder (C3H/HeJ) mice a reduction of the enzyme activity of over 40% was observed at a dose of 200 μg LPS. Tumour induction had no effect. In tumour-bearing mice of both strains the presence of a tumour seemed to interfere with the ability of LPS to depress hepatic catalase activity. Since a reduction of the enzyme activity in response to LPS or tumour induction seemed to be influenced by the LPS responsiveness of the mice, this study suggests that there could be common mediators of this effect. It is also possible that tumour induction might influence host responses to LPS.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-130-1-119
1984-01-01
2021-10-27
Loading full text...

Full text loading...

/deliver/fulltext/micro/130/1/mic-130-1-119.html?itemId=/content/journal/micro/10.1099/00221287-130-1-119&mimeType=html&fmt=ahah

References

  1. Diluzio N. R., Al-Tuwaijri A., Williams D. L., Kitahma A., Browder W. 1980; Modulation of host susceptibility to endotoxin by reticuloendothelial system stimulation or depression. In Bacterial Endotoxins and Host Response pp. 71–78 Edited by Agarwal M. K. New York: Elsevier/North-Holland Biomedical Press;
    [Google Scholar]
  2. Fujii S., Yuasa A., Kawachi T., Okamura Y., Wakasugi H., Yamamura Y. 1964; Purification of toxohormone by carboxymethylcellulose column chromatography. Gann 55:67–71
    [Google Scholar]
  3. Inomata M., Sekine T., Fukuoka F. 1976; Immunosuppressive activity of heat stable toxohormone fraction from cell-free fluid of ascites Sarcoma 180. Japanese Journal of Experimental Medicine 46:405–409
    [Google Scholar]
  4. Kampschmidt R. F., Clabaugh W. A. 1960; Indications of involvement of the reticuloendothelial system in alterations of iron metabolism produced by tumor extracts. Journal of the National Cancer Institute 25:713–718
    [Google Scholar]
  5. Kampschmidt R. F., Upchurch H. F. 1963; Effect of bacterial contamination of the tumor on tumor-host relationships. Cancer Research 23:756–761
    [Google Scholar]
  6. Kampschmidt R. F., Goodwin W. L., Mayne M. A. 1960; Iron metabolism and organ weights of rats with turpentine inflammation. Journal of the National Cancer Insitute 24:673–678
    [Google Scholar]
  7. Kampschmidt R. F., Schultz G., Mckinzie P. 1962; Effects of lipopolysaccharides derived from bacteria and tumor tissues on liver catalase activity, plasma iron concentration and organ weights. Journal of the National Cancer Institute 28:845–851
    [Google Scholar]
  8. Kaplan J. H., Groves J. N. 1972; Liver and blood cell catalase activity of tumor-bearing mice. Cancer Research 32:1190–1194
    [Google Scholar]
  9. Masuno H., Yamasaki N., Okuda H. 1981; Purification and characterization of a lipolytic factor (toxohormone-L) from cell-free fluid of ascites Sarcoma 180. Cancer Research 41:284–288
    [Google Scholar]
  10. Nakahara W. 1960; A chemical basis for tumor- host relations. Journal of the National Cancer Institute 24:77–86
    [Google Scholar]
  11. Nakahara W., Fukuoka F. 1958; The newer concept of cancer toxin. Advances in Cancer Research 5:157–177
    [Google Scholar]
  12. Peavy D. L., Brandon C. L. 1980; Macrophages: primary targets for LPS activity. In Bacterial Endotoxins and Host Response pp. 299–309 Edited by Agarwal M. K. New York: Elsevier/North- Holland Biomedical Press;
    [Google Scholar]
  13. Pike M. C., Snyderman R. 1976; Depression of macrophage function by a factor produced by neoplasms: a mechanism for abrogation of immune surveillance. Journal of Immunology 117:1243–1249
    [Google Scholar]
  14. Rosenstreich D. L., Vogel S. N. 1980; Central role of macrophages in the host response to endotoxin. In Microbiology-1980 pp. 11–15 Edited by Schlessinger D. Washington, D.C.: American Society for Microbiology;
    [Google Scholar]
  15. Snyderman R., Verghese M. W. 1980; Genetic control of leukocyte responses to endotoxic lipopoly- saccharide in mice. In Microbiology-1980 pp. 25–29 Edited by Schlessinger D. Washington, D.C.: American Society for Microbiology;
    [Google Scholar]
  16. Thomson J. F., Nance S. L., Tollaksen S. L. 1978; Spectrophotometric assay of catalase with perborate as substrate. Proceedings of the Society of Experimental Biology and Medicine 157:33–35
    [Google Scholar]
  17. Watanabe M. 1979; Immunosuppression induced by “toxohormone” from mouse tumor cells in culture. Tohoku Journal of Experimental Medicine 128:233–239
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-130-1-119
Loading
/content/journal/micro/10.1099/00221287-130-1-119
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error