1887

Abstract

A-factor is a potent pleiotropic effector produced by and is essential for streptomycin production and spore formation in this organism. Its production is widely distributed among various actinomycetes including A3(2). Genetic analysis of A-factor production was carried out with A3(2), and two closely linked loci for A-factor mutations ( and ) were identified between and on the chromosomal linkage map. In contrast, genetic crosses of A-factor-negative mutants of , using a protoplast fusion technique, failed to give a fixed locus for A-factor gene(s) and suggested involvement of an extrachromosomal or transposable genetic element in A-factor synthesis in this organism.

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/content/journal/micro/10.1099/00221287-129-9-2939
1983-09-01
2021-05-13
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