Summary: A-factor is a potent pleiotropic effector produced by and is essential for streptomycin production and spore formation in this organism. Its production is widely distributed among various actinomycetes including A3(2). Genetic analysis of A-factor production was carried out with A3(2), and two closely linked loci for A-factor mutations ( and ) were identified between and on the chromosomal linkage map. In contrast, genetic crosses of A-factor-negative mutants of using a protoplast fusion technique, failed to give a fixed locus for A-factor gene(s) and suggested involvement of an extrachromosomal or transposable genetic element in A-factor synthesis in this organism.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error