1887

Abstract

SUMMARY: Treatment of with the alkylating agents diethyl sulphate, ethyl methane-sulphonate and -methyl-'-nitro--nitrosoguanidine produces a different pattern of expression of SOS functions. There is a full induction of -dependent inhibition of cell respiration, a slight induction of lambda prophage, and no inhibition of cellular division. In a comparative study with bleomycin; an agent which is able to induce these three SOS functions, we have also shown that the differences in expression of SOS functions are not due to any variation in the pattern of DNA synthesis, or DNA degradation after treatment with alkylating agents. These results suggest that the kind of damage induced in the DNA may be important in determining which SOS function is expressed.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-129-7-2079
1983-07-01
2020-10-24
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-129-7-2079
Loading

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error