1887

Abstract

SUMMARY: This work describes isolation and characterization of mutants resistant to the lysine analogue -(2-aminoethyl)-L-cysteine (AEC). The mutation to AEC resistance was shown to affect the feedback regulation of aspartokinase; 70% of the mutants isolated had aspartokinase activity insensitive to concerted feedback inhibition by lysine plus threonine. Among these mutants, 70% (about 50% of the total AEC-resistant strains isolated) showed significant overproduction of β-lactam antibiotics.

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/content/journal/micro/10.1099/00221287-129-7-2063
1983-07-01
2019-10-21
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-129-7-2063
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