1887

Abstract

The coordination of growth with cell division in has been examined by investigating the order and interactions of three early events in the cell cycle. ‘Start’, which is thought to be the central control point from which alternative developmental pathways diverge ( Hartwell, 1974 ). preceded bud emergence by about 15 min regardless of cell growth rate. Cells growing in rich media showed the greatest increase in volume between ‘start’ and bud emergence. A nutrient-modulated cell size control event ( Lorincz & Carter, 1979 ) was executed coincident with, or after, ‘start’. Therefore, this latter step appears to be the primary point for cell size control in the cell cycle.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-129-6-1599
1983-06-01
2021-07-24
Loading full text...

Full text loading...

/deliver/fulltext/micro/129/6/mic-129-6-1599.html?itemId=/content/journal/micro/10.1099/00221287-129-6-1599&mimeType=html&fmt=ahah

References

  1. Beran K. 1968; Budding of yeast cells, their scars and ageing. Advances in Microbial Physiology 2:143–171
    [Google Scholar]
  2. Ciejek E., Thorner J. 1979; Recovery of S. cerevisiae a cells from G1 arrest by α-factor requires endopeptidase action. Cell 18:623–635
    [Google Scholar]
  3. Duntze W., Stotzler D., Bucking-Throm E., Kalbitzer S. 1973; Purification and partial characterization of α-factor, a mating type specific inhibitor of cell reproduction from Saccharomyces cerevisiae. European Journal of Biochemistry 35:357–365
    [Google Scholar]
  4. Hartwell L. H. 1974; Saccharomyces cerevisiaecell cycle. Bacteriological Reviews 38:164–198
    [Google Scholar]
  5. Hartwell L. H., Unger M. W. 1977; Unequal division in Saccharomyces cerevisiaeand its implications for the control of cell division. Journal of Cell Biology 75:422–435
    [Google Scholar]
  6. Hereford L. M., Hartwell L. H. 1974; Sequential gene function in the initiation of Saccharomyces cerevisiaeDNA synthesis. Journal of Molecular Biology 84:445–461
    [Google Scholar]
  7. Jagadish M. N., Carter B. L. A. 1977; Genetic control of cell division in yeast cultured at different growth rates. Nature; London: 269145–147
    [Google Scholar]
  8. Jarvick J., Botstein D. 1973; A genetic method for determining the order of events in a biological pathway. Proceedings of the National Academy of Sciences of the United States of America 70:2046–2050
    [Google Scholar]
  9. Johnston G. C., Pringle J. R., Hartwell L. H. 1977; Coordination of growth with cell division in the yeast Saccharomyces cerevisiae. Experimental Cell Research 105:79–98
    [Google Scholar]
  10. Johnston G. C., Ehrhardt C. W., Lorincz A., Carter B. L. A. 1979; Regulation of cell size in the yeast Saccharomyces cerevisiae. Journal of Bacteriology 137:1–5
    [Google Scholar]
  11. Lorincz A., Carter B. L. A. 1979; Control of cell size at bud initiation in Saccharomyces cerevisiae. Journal of General Microbiology 113:287–295
    [Google Scholar]
  12. Sebastian J., Carter B. L. A., Halvorson H. O. 1971; Use of yeast populations fractionated by zonal centrifugation, to study the cell cycle. Journal of Bacteriology 108:1045–1050
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-129-6-1599
Loading
/content/journal/micro/10.1099/00221287-129-6-1599
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error