Phenazine production by Pseudomonas phenazinium was not reduced by high concentrations of phosphate during batch culture (cf. Pseudomonas aeruginosa) but was inhibited by high concentrations of (NH4)2SO4 (1 to 10 g 1−1). In carbon-, sulphate-, magnesium- and potassium-depleted medium phenazine production paralleled growth. In continuous culture, phenazine production occurred over a wide range of growth rates under various nutrient-limiting conditions. At low growth rates cell resources were conserved and cell mass was maintained at the expense of secondary metabolite production. Low oxygen tensions and the addition of phenylalanine (0.1 g 1−1) each inhibited phenazine production.
ByngG. S.,
TurnerJ. M.1977; Incorporation of [14C]shikimate into phenazines and their further metabolism by Pseudomonas phenazinium. Biochemical Journal 164:139–145
CalhounD. H.,
CarsonM.,
JensenR. A.1972; The branch point metabolite for pyocyanine biosynthesis in Pseudomonas aeruginosa. Journal of General Microbiology 72:581–583
DemainA. L.,
KennelY. M.,
AharonowitzY.1978; Carbon catabolite regulation of secondary metabolism. Symposia of the Society for General Microbiology 29:163–185
HadijpetrouL. P.,
GerritsJ. P.,
TeulingsF. A. G.,
StouthamerA. H.1964; Relation between energy production and growth of Aerobacter aerogenes. Journal of General Microbiology 36:139–150
KannerD.,
GerberN. M.,
BarthaR.1978; Pattern of phenazine pigment production by a strain of Pseudomonas aeruginosa. Journal of Bacteriology 134:690–692
KorthH.1974; Mixed carbon source effect in the phenazine-a-carboxylic acid synthesis and the aromatic pathway in Pseudomonas spp. Archiv für Mikrobiologie 97:245–252
LabeyrieS.,
NeuzilE.1981; Influence of supplementary tyrosine or phenylalanine on bacterial growth and pigmentation of Pseudomonas aeruginosa. Annales de Microbiologie 132A:31–l40
LongleyR. P.,
HalliwellJ. E.,
CampbellJ. J. R.,
IngledewW. M.1972; The branchpoint of pyocyanine biosynthesis. Canadian Journal of Microbiology 18:1357–1368
WardA. C.,
PackterN. M.1974; Relationship between fatty acid and phenol synthesis in Aspergillus fumigatus. European Journal of Biochemistry 46:323–333