SUMMARY: strain GLA0 (= ETH 22794) produces hydroxystreptomycin and has a high natural resistance to hydroxystreptomycin, dihydrostreptomycin and streptomycin. The wild-type strain gives rise spontaneously to streptomycin-sensitive (StrS) variants at a frequency of 0.2 to 1.4%. These mutants lack streptomycin phosphotransferase activity responsible for the wild-type resistance to streptomycin group antibiotics and are unable to produce detectable amounts of hydroxystreptomycin.

Mapping experiments showed that the marker lies between the chromosomal markers and on the linkage map of The molecular basis for instability of this marker is as yet unknown.


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