CDA is a New Chromosomally-determined Antibiotic from A3(2) Free

Abstract

Mutations () leading to non-production of the new calcium-dependent antibiotic (CDA) of A3(2) were closely linked on the chromosome. One representative mutation () was mapped precisely between and . No cosynthesis of CDA was found in any pairwise combinations of 14 mutants. Mutations lacking aerial mycelium (bald mutations), mapping to the four previously described loci (), were pleiotropically defective in production of CDA.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-129-12-3575
1983-12-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/micro/129/12/mic-129-12-3575.html?itemId=/content/journal/micro/10.1099/00221287-129-12-3575&mimeType=html&fmt=ahah

References

  1. Delić V., Hopwood D. A., Friend E. J. 1970; Mutagenesis by N-methyl-N’-nitro-N-nitrosoguani- dine (NTG) in Streptomyces coelicolor. Mutation Research 9:167–182
    [Google Scholar]
  2. Hopwood D. A. 1967; Genetic analysis and genome structure in Streptomyces coelicolor. Bacteriological Reviews 31:373–403
    [Google Scholar]
  3. Hopwood D. A., Wright H. M. 1981; Protoplast fusion in Streptomyces:fusions involving ultraviolet- irradiated protoplasts. Journal of General Microbiology 126:21–27
    [Google Scholar]
  4. Hopwood D. A., Chater K. F., Dowding J. E., Vivian A. 1973; Advances in Streptomyces coelicolor genetics. Bacteriological Reviews 37:371–405
    [Google Scholar]
  5. Hornemann U., Hopwood D. A. 1981; Biosynthesis of methylenomycin A: a plasmid-determined antibiotic. In Antibiotics. IV. Biosynthesis pp. 123–131 Corcoran J. W. Edited by Berlin, Heidelberg & New York: Springer-Verlag;
    [Google Scholar]
  6. Kirby R., Wright L. F., Hopwood D. A. 1975; Plasmid-determined antibiotic synthesis and resistance in Streptomyces coelicolor. Nature; London: 254265–267
    [Google Scholar]
  7. Lakey J., Lea E. A., Hopwood D. A., Rudd B.A.M., Wright H. M. 1983; A new chAnnél forming antibiotic from Streptomyces coelicolorA3(2) which requires calcium for its activity. Journal of General Microbiology 129:3565–3573
    [Google Scholar]
  8. Merrick M. J. 1976; A morphological and genetic mapping study of bald colony mutants of Streptomyces coelicolor. Journal of General Microbiology 96:299–315
    [Google Scholar]
  9. Rudd B.A.M. 1978 Genetics of pigmented secondary metabolites in Streptomyces coelicolor. Ph.D thesis University of East Anglia, Norwich, U.K.:
    [Google Scholar]
  10. Rudd B.A.M., Hopwood D. A. 1979; Genetics of actinorhodin biosynthesis by Streptomyces coelicolorA3(2). Journal of General Microbiology 114:35–43
    [Google Scholar]
  11. Rudd B.A.M., Hopwood D. A. 1980; A pigmented mycelial antibiotic in Streptomyces coelicolor: control by a chromosomal gene cluster. Journal of General Microbiology 119:333–340
    [Google Scholar]
  12. Wright L. F., Hopwood D. A. 1976a; Indentification of the antibiotic determined by the SCPl plasmid of Streptomyces coelicolor A3(2). . Journal of General Microbiology 95:96–106
    [Google Scholar]
  13. Wright L. F., Hopwood D. A. 1976b; Actinorho-din is a chromosomally-determined anti- biotic in Streptomyces coelicolor A3(2). Journal of General Microbiology 96:289–297
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-129-12-3575
Loading
/content/journal/micro/10.1099/00221287-129-12-3575
Loading

Data & Media loading...

Most cited Most Cited RSS feed