SUMMARY: Mice infected with , BCG, were shown to be highly susceptible to subsequent challenge with The susceptibility was characterized by the enhanced mortality and shortened survival after challenge with BCG-treated mice did not show any enhanced susceptibility to challenge with Gram-positive bacteria such as or BCG-treated mice eliminated from their organs in a pattern similar to that in untreated mice. There was no significant difference in the bactericidal activities of polymorphonuclear cells and macrophages between BCG-treated and untreated mice. An equal amount of endotoxin was detected by the Limulus lysate assay in the blood of both BCG-treated and untreated mice after challenge with The enhanced susceptibility induced by BCG pretreatment could be decreased when the mice were rendered LPS-tolerant by injections of small amounts of LPS. These results suggest that BCG-induced susceptibility to can be ascribed to an enhanced susceptibility to the lethal effect of LPS produced by challenge bacteria, and not to the impairment of the ability to eliminate infected bacteria.


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