SUMMARY: A new class of regulatory mutants in the locus has been isolated by plating strains, under anaerobic conditions, on medium containing 1,2,4-triazole. The isolated mutants are cysteine prototrophs and triazole-resistant, although the levels of cysteine and -acetyl--serine sulphydrylase are not changed. In contrast to the constitutive mutants identified previously, the expression of the cysteine biosynthetic enzymes in the newly isolated mutants is regulated by the same factors as in wild-type strains. In the double mutant , the cysteine biosynthetic enzymes are absent with the exception of -acetyl--serine sulphydrylase.


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