1887

Abstract

Transport of natural peptides and antibacterial phosphonopeptide analogues was studied in ATCC 9790. Competition studies, and the isolation of peptide-transport deficient mutants, indicate the presence of two peptide permeases. One is a high-rate system used by dipeptides, and to a lesser extent tripeptides; the other is a low-rate oligopeptide system. Following uptake, peptides are cleaved and their amino acid residues may undergo rapid exodus. Different strains of differ in their rates of peptide transport.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-128-6-1357
1982-06-01
2021-07-23
Loading full text...

Full text loading...

/deliver/fulltext/micro/128/6/mic-128-6-1357.html?itemId=/content/journal/micro/10.1099/00221287-128-6-1357&mimeType=html&fmt=ahah

References

  1. Allen J. G., Atherton F. R., Hall M. J., Hassall C. H., Holmes S. W., Lambert R. W., Nisbet L. J., Ringrose P. S. 1979; Phosphonopeptides as antibacterial agents: alaphosphin and related phosphonopeptides. Antimicrobial Agents and Chemotherapy 15:684–695
    [Google Scholar]
  2. Andrew M. H. E. 1973; Use of trimethoprim to obtain thymine-requiring mutants of Streptococcus faecalis. Journal of General Microbiology 74:195–199
    [Google Scholar]
  3. Asghar S. S., Levin E., Harold F. M. 1973; Accumulation of neutral amino acids by Streptococcus faecalis: energy coupling by a protonmotive force. Journal of Biological Chemistry 248:5225–5233
    [Google Scholar]
  4. Atherton F. R., Hall M. J., Hassall C. H., Lambert R. W., Ringrose P. S. 1979; Phosphonopeptides as antibacterial agents: rationale, chemistry and structure-activity relationships. Antimicrobial Agents and Chemotherapy 15:677–683
    [Google Scholar]
  5. Barker E. P., Harold F. M. 1980; Energy coupling to potassium transport in Streptococcus faecalis. Interplay of ATP and the protonmotive force. Journal of Biological Chemistry 255:433–440
    [Google Scholar]
  6. Brock T. D., Moo-Penn G. 1962; An amino acid transport system in Streptococcus faecium. Archives of Biochemistry and Biophysics 98:183–190
    [Google Scholar]
  7. Brock T. D., Woolley S. O. 1964; Glycylglycine uptake in streptococci and a possible role of peptides in amino acid transport. Archives of Biochemistry and Biophysics 105:51–57
    [Google Scholar]
  8. Diddens H., Dorgerloh M., Zahner H. 1979; Metabolic products of microorganisms: on the transport of small peptide antibiotics in bacteria. Journal of Antibiotics 32:87–90
    [Google Scholar]
  9. Holden J. T., Bunch J. M. 1973; Asparagine transport in Lactobacillus plantarum and Streptococcus faecalis. Biochimica et biophysica acta 307:640–655
    [Google Scholar]
  10. Kihara H., Klatt O. A., Snell E. E. 1952; Peptides and bacterial growth. III. Utilization of tyrosine and tyrosine peptides by Streptococcus faecalis. Journal of Biological Chemistry 197:801–807
    [Google Scholar]
  11. Kihara H., Ikawa M., Snell E. E. 1961; Peptides and bacterial growth. X. Relation of uptake and hydrolysis to utilization of d-alanine peptides for growth of Streptococcus faecalis. Journal of Biological Chemistry 236:172–176
    [Google Scholar]
  12. Nisbet T. M. 1980 Aspects of peptide transport in Saccharomyces cerevisiae and Streptococcus spp Ph.D. thesis: Durham University, U.K;
    [Google Scholar]
  13. Nisbet T. M., Payne J. W. 1979; Peptide uptake in Saccharomyces cerevisiae: characteristics of transport system shared by di- and tripeptides. Journal of General Microbiology 115:127–133
    [Google Scholar]
  14. Nisbet T. M., Payne J. W. 1980; Characterization of two peptide transport systems in Streptococcus faecalis. Biochemical Society Transactions 8:705–706
    [Google Scholar]
  15. Payne J. W. 1975; Transport of peptides in microorganisms. In Peptide Transport in Protein Nutrition pp. 365–391 Edited by Matthews D. M., Payne J. W. Amsterdam: North Holland/ Elsevier;
    [Google Scholar]
  16. Payne J. W. 1980; Transport and utilization of peptides by bacteria. In Microorganisms and Nitrogen Sources pp. 211–256 Edited by Payne J. W. Chichester: John Wiley;
    [Google Scholar]
  17. Payne J. W., Bell G. 1977; Substrate interactions during transport of amino acids and peptides by Escherichia coli: relevance to regulation of peptide uptake. FEMS Microbiology Letters 2:301–304
    [Google Scholar]
  18. Payne J. W., Bell G. 1979; Direct determination of the properties of peptide transport systems in Escherichia coli, using a fluorescent-labeling procedure. Journal of Bacteriology 137:447–455
    [Google Scholar]
  19. Payne J. W., Gilvarg C. 1978; Transport of peptides in bacteria. In Bacterial Transport pp. 325–384 Edited by Rosen B. P. New York: Marcel Dekker;
    [Google Scholar]
  20. Payne J. W., Nisbet T. M. 1980; Limitations to the use of radioactively labelled substrates for studying peptide transport in microorganisms. FEBS Letters 119:73–76
    [Google Scholar]
  21. Payne J. W., Nisbet T. M. 1981; Continuous monitoring of substrate uptake by microorganisms using fluorescamine: application to peptide transport by Saccharomyces cerevisiae and Streptococcus faecalis. Journal of Applied Biochemistry 3: (in the Press)
    [Google Scholar]
  22. Perry D. 1981; Peptide transport in Staphylococcus aureus. Journal of General Microbiology 124:425–428
    [Google Scholar]
  23. Perry D., Abraham E. P. 1979; Transport and metabolism of bacilysin and other peptides by suspensions of Staphylococcus aureus. Journal of General Microbiology 115:213–221
    [Google Scholar]
  24. Ringrose P. S. 1980; Peptides as antimicrobial agents. In Microorganisms and Nitrogen Sources pp. 641–692 Edited by Payne J. W. Chichester: John Wiley;
    [Google Scholar]
  25. Ringrose P. S., Lloyd W. J. 1979; Permease exploitation by the antibacterial peptide mimetic alafosfalin. 11th International Congress of Biochemistry abstract 06-8-R69
    [Google Scholar]
  26. Staskawicz B. J., Panopoulos N. J. 1980; Phaseolotoxin transport in Escherichia coli and Salmonella typhimurium via the oligopeptide permease. Journal of Bacteriology 142:474–479
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-128-6-1357
Loading
/content/journal/micro/10.1099/00221287-128-6-1357
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error