1887

Abstract

Variants of P9 possessing , or pili were shown to vary in their toxicity and virulence for human epithelial cells. Studies with antisera raised against purified pili showed that attachment and virulence were reduced to a significant degree in the presence of antisera to homologous pili. Heterologous antisera, while capable of agglutinating whole organisms, were largely ineffective in reducing attachment and cytotoxicity. Using an enzyme-linked immunosorbent assay (ELISA) system, the cross-reactivity between pili and heterologous antisera was estimated to be no more than 10–20%.

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1982-05-01
2021-07-24
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References

  1. Diaz J.-L., Heckels J. E. 1982; Antigenic variation of outer membrane protein II in colonial variants of Neisseria gonorrhoeae P9. Journal of General Microbiology 128:585–591
    [Google Scholar]
  2. Lambden P. R., Heckels J. E. 1979; Outer membrane protein composition and colonial morphology of Neisseria gonorrhoeae strain P9. FEMS Microbiology Letters 5:263–265
    [Google Scholar]
  3. Lambden P. R., Heckels J. E., Mcbride H. M., Watt P. J. 1981a; The identification and isolation of novel pilus types produced by variants of Neisseria gonorrhoeae P9 following selection in vivo . FEMS Microbiology Letters 10:339–341
    [Google Scholar]
  4. Lambden P. R., Robertson J. N., Watt P. J. 1981b; The preparation and properties of α and β pili from variants of Neisseria gonorrhoeae P9. Journal of General Microbiology 124:109–117
    [Google Scholar]
  5. Lind I., Reimann K. 1980; Studies of the antigenic heterogeneity of N. gonorrhoeae pilus antigens. In Genetics and Immunobiology of Pathogenic Neisseria pp. 95–97 Danielsson E., Normark S. Edited by Proceedings of an EMBO Workshop, Hemavan, Sweden:
    [Google Scholar]
  6. Mcbride H. M., Lambden P. R., Heckels J. E., Watt P. J. 1981; The role of outer membrane proteins in the survival of Neisseria gonorrhoeae P9 within guinea-pig subcutaneous chambers. Journal of General Microbiology 126:63–67
    [Google Scholar]
  7. Novotny P., Cownley K. 1980; Investigation of serological cross-reactions between gonococcal pili. In Genetics and Immunobiology of Pathogenic Neisseria pp. 91–93 Danielsson D., Normark S. Edited by Proceedings of an EMBO Workshop, Hemavan, Sweden:
    [Google Scholar]
  8. Penn C. W., Parsons N. J., Veale D. R., Smith H. 1978; Correlation with different immunotypes of gonococcal antigens associated with growth in vivo . Journal of General Microbiology 105:153–157
    [Google Scholar]
  9. Virji M. 1981; The effect of antibody directed against outer membrane antigens on the virulence of a pilated variant of Neisseria gonorrhoeae . FEMS Microbiology Letters 12:355–358
    [Google Scholar]
  10. Virji M., Everson J. S. 1981; Comparative virulence of opacity variants of Neisseria gonorrhoeae strain P9. Infection and Immunity 31:965–970
    [Google Scholar]
  11. Ward M. E., Watt P. J. 1977; The role of specific and non-specific factors in the interaction of gonococci with host cells. In Gonorrhoea: Epidemiology and Pathogenesis pp. 83–95 Skinner F. A., Walker P. D., Smith H. Edited by London: Academic Press.;
    [Google Scholar]
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