%0 Journal Article %A Thompson, Jill %A Cundliffe, Eric %A Stark, Michael J. R. %T The Mode of Action of Berninamycin and the Mechanism of Resistance in the Producing Organism, Streptomyces bernensis %D 1982 %J Microbiology, %V 128 %N 4 %P 875-884 %@ 1465-2080 %R https://doi.org/10.1099/00221287-128-4-875 %I Microbiology Society, %X The mode of action of berninamycin on bacterial protein synthesis is related to that of thiostrepton, a dissimilar compound. Both antibiotics bind to the complex of 23S RNA with protein L11 and both affect various functions of the ribosomal A site. Also, Streptomyces bernensis and Streptomyces azureus (which, respectively, produce berninamycin and thiostrepton) possess similar ribosomal RNA methylases capable of rendering ribosomes resistant to these compounds. Resistance involves specific pentose-methylation of 23S ribosomal RNA. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-128-4-875