1887

Abstract

SUMMARY: The mode of action of berninamycin on bacterial protein synthesis is related to that of thiostrepton, a dissimilar compound. Both antibiotics bind to the complex of 23S RNA with protein L11 and both affect various functions of the ribosomal A site. Also, and (which, respectively, produce berninamycin and thiostrepton) possess similar ribosomal RNA methylases capable of rendering ribosomes resistant to these compounds. Resistance involves specific pentose-methylation of 23S ribosomal RNA.

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/content/journal/micro/10.1099/00221287-128-4-875
1982-04-01
2019-10-19
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-128-4-875
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