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Galactitol-positive strains of Escherichia coli K12 are inhibited by the galactitol analogues l-fucitol and 2-deoxy-d-galactitol, but not by d-fucitol; Salmonella typhimurium LT2 is not inhibited by these compounds. Most mutants selected as resistant to either toxic compound are unable to utilize galactitol as carbon source, but a relatively rare class is inducible for the Enzyme II of the galactitol: phosphoenolpyruvate phosphotransferase system, the product of which is d-galactitol 6-phosphate. The lesion in one such mutant maps near metG at about min 45 on the E. coli genome.
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