1887

Abstract

In , the intracellular and the extracellular enzyme forms of tyrosinase were found to be identical in molecular weight (29000), in copper content (0·21%), in the 19 amino acids at the amino-terminal end and in the ratio of cresolase to catecholase activity (0·005). The tyrosinase secretion process exhibited a constant rate of 0·15 units h (mg protein). Under highly induced conditions intracellular tyrosinase was accumulated. Mutations responsible for the non-melanogenic, tyrosinase-positive non-secretor mutant type are located chromosomally on the upper right arc of the map near the marker.

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1982-02-01
2021-07-30
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