@article{mbs:/content/journal/micro/10.1099/00221287-128-12-3067, author = "Nakamura, H. and Yokomura, E. and Hirayoshi, K.", title = "Effect of Acriflavine on the Plasma Membrane of Escherichia coli K12", journal= "Microbiology", year = "1982", volume = "128", number = "12", pages = "3067-3070", doi = "https://doi.org/10.1099/00221287-128-12-3067", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-128-12-3067", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Plasma membranes of acriflavine-sensitive mutant (acrA) and acriflavine-resistant (acrA +, wild-type and true revertant) Escherichia coli K12 strains treated with acriflavine were observed under the electron microscope by means of the freeze-fracture technique. The plasma membrane of the acrA mutant exhibited a complex lamellar structure at the end of the cell when treated with 20 μg acriflavine ml−1. However, the membrane of the acrA + cells also gave the lamellar complex when treated with a very high concentration of acriflavine (100 μg ml−1) The size of the intramembranous particles was not affected by the acriflavine treatments", }