SUMMARY: Addition of particles to growing cultures of the amoeba, resulted in the production of large amounts of AMP, much of which was found extracellularly. At the time of maximal AMP production (13 h growth) adenylate energy charge values in conditioned and fresh medium were 0·58 and 0·1, respectively. Removal of particles from growth medium by filtration lowered the AMP level to 22% of the control value at the time of maximal AMP production; addition of particles to conditioned medium raised the level of AMP 3·6-fold.

Uptake of killed yeast was accompanied by relatively small changes in levels of ATP and ADP, but large (5·7-fold) changes in AMP levels. Successive cycles of phagocytosis were paralleled by cyclic changes in AMP levels.


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