SUMMARY: grown on glucose (1 %, w/v) medium exhibited diauxic growth because of the transition from catabolite-repressed fermentative metabolism to derepressed oxidative metabolism. 3-Hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase; EC was object to catabolite repression and required cytoplasmic protein synthesis for derepression. The addition of glucose (2 %, w/v) at up to 4 h prior to glucose exhaustion had no effect on subsequent derepression of HMG-CoA reductase, suggesting that the enzyme was irreversibly committed to derepression at this stage. However, other derepressible enzyme activities such as NAD-dependent glutamate dehydrogenase (EC and malate dehydrogenase (EC did not show a commitment to derepression at this time. In contrast, NADP-dependent glutamate dehydrogenase (EC was induced by the addition of glucose.


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