Loss of Nitrofuran Resistance in is Correlated with Loss of a 46·7 kb Circular DNA Molecule Free

Abstract

Strain FC1, a wild-type isolate of the phytopathogenic fungus , is resistant to nifuroxime, a nitrofuran derivative. Mutants sensitive to this compound arise at high frequency by vegetative segregation. Resistance to nifuroxime is inherited as an extranuclear marker in crosses between a nifuroxime-sensitive variant and the wild-type. Nifuroxime-sensitive strains are also unable to express an exopolygalacturonase activity present in the wild-type. For one strain tested, it was shown that the ability to parasitize a susceptible tomato plant variety was also lost. Loss of nifuroxime resistance was concomitant with the loss of a 46·7 kb circular DNA molecule.

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1982-10-01
2024-03-29
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