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Both early- and late-exponential phase cells of Acanthamoeba castellanii possess a terminal oxidase which by 1 mm-cyanide but not by azide, salicylhydroxamic acid or CO. In early-exponential organisms this oxidase has a low affinity for O2, but in late-exponential it is modified or replaced by an oxidase which can function rapidly at around 1 μm-O2
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